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46 , 161 Even large molecules, such as the enzyme -galactosidase, have been successfully transported into the CNS via similar methods of bioactive conjugation
Elevated IL-6 and TNF-alpha levels in patients with ALS: inflammation or hypoxia
In extreme cases, septic shock may also arise from increased microbial translocation into the bloodstream, with mortality rates of up to 70% being reported (Matot and Sprung 2001
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