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A triple combination therapy of liraglutide, metformin, and TZD for 26 weeks in 533 subjects (1:1:1) randomized to once-daily liraglutide (1.2 or 1.8 mg) or liraglutide placebo in combination with metformin (1 g twice daily) and rosiglitazone (4 mg twice daily) demonstrated significantly greater mean HbA1c values in the liraglutide groups versus placebo (mean SE, -1.5 0.1% for both 1.2 and 1.8 mg liraglutide and -0.5 0.1% for placebo)

Gag reflex in the certification of brain death We are legally required to confirm the absence of a gag reflex in every patient who is declared brain dead

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51 Obstructive sleep apnoea In a one-year study of adults with moderate to severe obstructive sleep apnoea and obesity about half of whom were treated with positive airway pressure at baseline tirzepatide 10 or 15 mg once weekly resulted in a clinically meaningful reduction in the apnoeahypopnoea index compared with placebo