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The accumulation of amphetamines effectively reverses the transporter carrier mechanisms, leading to a massive, non-exocytotic efflux of vesicular dopamine out into the cytosol, where it is subsequently transported into the synaptic cleft (Wimalasena 2011)(see Figure 2 Mechanism B)

At physiological levels, ROS functions as signalling mediators, regulates various physiological functions such as the growth, proliferation, and migration endothelial cells (EC) and smooth muscle cells (SMC)