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Firmer stools : The slower gut motility causes water from the stool to be reabsorbed in the colon making stools firmer and more difficult to pass

According to FDA prescribing information and clinical trial data, nausea is the most common adverse effect, occurring in 15-44% of patients depending on the specific medication and dose

Serine and glycine metabolism, derived from glycolytic 3-phosphoglycerate, provide advantages for cell growth, such as nucleotide synthesis, DNA methylation, glutathione production and NADPH generation

Investigations on fixed-dose combinations (FDCs) containing DPP-4 inhibitors as monotherapy are also underway to improve treatment simplification and medication adherence