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33 demonstrated that Gli2 is the key mediator of Shh responses in the skin, and Gli2 controls epithelial cell proliferation in embryonic skin through transcriptional regulation of cyclin D1 and D2, we believed that Shh signaling participated in the process of active hair-follicle density increase through Gli2

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Peer review Peer review information Communications Medicine thanks Arun Thirunavukarasu, Sheyu Li and the other, anonymous, reviewer(s) for their contribution to the peer review of this work