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A major step toward understanding this relationship occurred when we determined that the AT4 receptor antagonist Norleual-AngIV (Nle-Tyr-Leu-(CH2-NH2)3-4-His-Pro-Phe) inhibited HGF binding to Met and HGF-dependent cell signaling, proliferation, invasion, and scattering [81]

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Given the extensive and heterogeneous body of literature availablecharacterized by varying levels of evidence qualityreaders are referred to dedicated, topic-specific reviews for more comprehensive insights and detailed analyses [108,109,110]