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Tirzepatide is a dual agonist for the glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors

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For these reasons, PregS more closely resembles the characteristics of classical neurotransmitters, such as acetylcholine, in which the parent molecule bears a full positive charge and is active only at an extracellularly directed recognition site while the immediate breakdown products (choline + acetic acid) are inactive

Long-term research will also guide clinical guidelines by clarifying maintenance strategies, cardiovascular outcomes, and optimal discontinuation protocols all of which affect value calculations for patients and payers