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NF-kappaB ist ein zentraler Transkriptionsfaktor, der die Expression hunderter entzuendungsfoerdernder Gene steuert

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When caspase-8 activity is inhibited, TRAF2 prompts RIPK1 to bind RIPK3 with the formation of a necrosome complex also known as ripoptosome [209]

TP53 mutations in AML patients are associated with dismal clinical outcome irrespective of frontline induction regimen and allogeneic hematopoietic cell transplantation