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But, and this is a significant but, these were male rats, which is a particularly significant limitation given that fibromyalgia has an approximately 3:1 female-to-male prevalence ratio and reserpine-induced models have known sex differences in their mechanisms

GLP-1 Receptor Activity The glucagon-like peptide-1 receptor regulates pancreatic insulin secretion, slows gastric emptying, and reduces appetite through central pathways [3]