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The study was a randomized, double-blind, parallel, placebo-controlled trial with 24 obese males aged 19-49 years in two groups: MK-677 (25 mg/day

You may notice digestive changes early on and your provider may recommend lower starting doses and dietary adjustments to manage fat digestion

The pills havent been compared head-to-head in a clinical trial, but in separate studies, the Wegovy pill showed average weight loss of 14% over 64 weeks, compared with 2% for a placebo, while orforglipron showed 11% weight loss over 72 weeks on its highest dose, compared with 2% for the placebo group

This means that there is less ability in the cells of people with Down syndrome to perform the chemical reaction (methylation)