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Long-term studies, such as, for example, the UK Prospective Diabetes Study (UKPDS), have suggested that good glycemic memory leads to a significant reduction in any diabetes-related endpoint
doi: 10.1530/eje.0.1420315
Smith W, Diaz GA, Lichter-Konecki U, Berry SA, Harding CO, McCandless SE, LeMons C, Mauney J, Dickinson K, Coakley DF, Moors T, Mokhtarani M, Scharschmidt BF, Lee B (2013) Ammonia control in children ages 2 months through 5 years with urea cycle disorders: comparison of sodium phenylbutyrate and glycerol phenylbutyrate
One possibility is that GLP-1s activate the sympathetic nervous system, which can raise the heart rate
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