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When YAP is activated in organoids, it increases the expression of downstream target genes, including connective tissue growth factor ( Cgtf ) and cysteine-rich angiogenic inducer 61 ( Cyr61 )

As large molecule therapeutics drive viscosities into the hundreds, or even thousands, of centipoise range,1 and enzymatic adjuncts2 enable subcutaneous injections well above conventional 2 mL delivery volumes, it is necessary to reinvent the legacy spring-powered autoinjector platform to enable the self-administration of these truly revolutionary therapies

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