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& Salles, G
As a potent antioxidant, Glutathione shields cells from potential harm inflicted by detrimental substances
In contrast, free proline and 4-hydroxyproline in the lumen are taken up into the cells primarily by the Na + -dependent system IMINO transporter and the system NBB transporter (present on the brush border for the transport of neutral amino acids), as well as the Na + -independent system L transporter (Brandsch 2006)
Inactivating NUDT15 variants impair the breakdown of Rac1-binding TGTPs and sensitize Asians to thiopurine toxicity ( TPMT variants resulting in low TPMT activity skews the thiopurine pathway to produce excessive 6-TGNs ( Together, the two diverging routes of metabolism are gatekeepers of thiopurine toxicity
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