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Bioinformatics analysis The software DAVID ( was used to perform enrichment analysis, and the method used was Fishers exact test to perform GO functional significance enrichment analysis on differential proteins

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The application of NE technology enables the formulation of PHY-based systems with particle sizes typically ranging from 100 to 500 nm, exhibiting superior solubility, physicochemical stability, bioavailability, and prolonged systemic half-life (108)

Basophils store inflammatory mediators such as IL-4 and TNF- , as well as histamine, releasing them upon IgE crosslinking with surface receptors (Schwartz et al., 2016)