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Willmore, Redox regulation of mitochondrial function with emphasis on cysteine oxidation reactions

The OGTT and the Child-Pugh score were independent predictors of death, suggesting that there might be a synergistic effect between conditions.17 DM might induce liver damage by promoting inflammation and fibrosis through an increase in mitochondrial oxidative stress by the action of leptin, adiponectin, interleukin-6 and TNF-, which are produced in chronically inflamed adipose tissue (adipositis).19,20 The production of these chemical mediators is stimulated by insulin resistance (RI)

Metformin improves insulin sensitivity and helps regulate blood sugar, which may reduce fat storage and appetite

When used in combination, they exhibit remarkable synergistic effects