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Graphical abstract Similar content being viewed by others Introduction The digestive system, extending from the oral cavity to the rectum, is a pivotal organ system responsible for nutrient absorption, immune defense, and metabolic regulation [1, 2]

mtGSH acts as a suppressor of cuproptosis, as depletion of the mtGSH importer SLC25A39 , increases cellular sensitivity to cuproptosis 169

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BPC-157 is derived from a gastric peptide fragment, TB-500 is a synthetic analog of thymosin beta-4 studied for actin-related processes, GHK-Cu is a copper-binding tripeptide frequently examined in extracellular matrix and biomarker research, and KPV is a short peptide fragment explored in preclinical settings for immunomodulatory signaling pathways