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Healthcare professionals increasingly recognize that obesity is a complex medical condition rather than simply a matter of willpower

Interestingly, despite the lack of consistent actions of metformin in terms of metabolic profiles, treatment with the insulin sensitizer caused a complete normalization of ovarian cyclicity, pointing to a discernible reproductive effect of metformin in some PCOS conditions, in line with clinical literature 68 , although conflictive results have been reported also 69

Discontinuation rates in trials range from 2040% due to tolerability issues, making this medication challenging for sensitive individuals

Food Chem 372:131272