why does tirzepatide work better than semaglutide or why does semaglutide work better

Combined activation of GLP-1, GIP, and GCG systems theoretically provides complementary mechanisms: GLP-1-mediated insulin sensitization and satiety promotion, GIP-mediated enhancement of insulin secretion and adipose lipid buffering, and glucagon-mediated direct hepatic lipid oxidation and energy expenditure augmentation

[DOI] [PMC free article] [PubMed] [Google Scholar] 29.Salminen A., Kauppinen A., Kaarniranta K

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Like GLP-1, it increases satiety by slowing gastric emptying & changing our appetite preferences