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effects vary substantially based on baseline fitness, protein intake, and exercise engagement Protective interventions: Resistance training and higher protein intake (1.2-1.6 g/kg/day) are the evidence-supported approaches to minimizing lean mass loss What readers should know: GLP-1 drugs can be appropriate and beneficial for older adults with obesity or type 2 diabetes

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Potential Complications and Management of Large CMN Potential Complications and Management of Large CMN Large CMN can be associated with systemic disease (eg, affecting the central nervous system [CNS]), whereas the consequences of small and medium-sized CMN are usually limited to the skin