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Written informed consent to participate in this study was provided by the participants or their legal guardian/next of kin

Most familial cases of both ALS (~40%) and FTD (25%) are associated with hexanucleotide (G4C2) expansions in the Chromosome 9 open reading frame 72 (C9orf72) gene (Dejesus-Hernandez et al., 2011

Unfortunately, pain scores were not assessed at any earlier points in this study, it is therefore unknown whether pain had decreased more in the B12 group at an earlier time point

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