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Long term secretion of Exe4 peptide in the genome-edited mice To examine the prolonged expression of Exe4 following a single genome editing procedure, we administrated HITI components, including the scExe4 donor with gRNA expression cassette and Cas9-expression DNAs, via intravenous injection of DNA-loaded LNPs into Balb/c mice (Fig

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The formation of atherosclerotic plaque is an early event in the development of coronary heart disease (CHD) and progresses slowly over many years