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Additionally, Semaglutide has FDA approval for reducing major cardiovascular events , such as heart attacks and strokes, in certain populations a benefit that is still being studied for tirzepatide

Common gastrointestinal effects reported with GLP-1 therapy include: Nausea (commonly reported, especially during dose escalation) Constipation or diarrhoea Abdominal discomfort or bloating Reduced appetite and early satiety Regarding bowel movement colour specifically, changes in stool colour are not listed as adverse effects in UK SmPCs for GLP-1 receptor agonists

Gastric sensory and motor functions and energy intake in health and obesitytherapeutic implications

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