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Nrf2/HO-1 blocks TXNIP/NLRP3 interaction via elimination of ROS in oxygen-glucose deprivation-induced neuronal necroptosis

5 Some theories suggest that glutathione can reduce the activity of the enzyme tyrosinase, which is involved in melanin production

For LigandScout-based pharmacophore screening (Wolber & Langer, 2004) libraries were converted to ldb format using the idbgen utility, applying the icon best preset and more (600) conformers to ensure adequate sampling of ligand flexibility