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In CVDs, oxidative stress drives endothelial dysfunction and cardiac remodeling [10, 11], while in cognitive impairment, it promotes AD hallmarks like amyloid- aggregation and tau hyperphosphorylation

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Table of Contents Understanding Leptin Resistance and Its Impact on Weight Management Leptin is a hormone produced primarily by adipose (fat) tissue that plays a crucial role in regulating energy balance and body weight

This may explain why multiple large-scale randomized controlled trials have failed to demonstrate significant preventive effects of Vitamin D 3 supplementation on autoimmune disease incidence ( 3 immune function relationship