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PCOS and GLP-1s: Improving Reproductive Functionality For PCOS, the human evidence on GLP-1 medications is compelling enough that they now feature in the 2023 International PCOS Guidelines, though as a conditional recommendation (1)

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Mechanistically, SAC directly interacts with Keap1 to promote Nrf2 into the nucleus, enhance the transcription of antioxidant genes (such as GPX4 and NQO1), and restore the biosynthesis of GSH