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Sublingual delivery can in principle bypass first-pass hepatic metabolism by absorbing through the oral mucosa directly into systemic circulation

The total energy of molecular system using OPLS-AA force field is a sum of the non-bonded energy E nb , bond stretching and angle bending terms E bond and E angle , and the torsional energy E torsion

They are involved also in the stimulation of mucin synthesis and in the preservation of gut barrier integrity, inducing TJ assembly