Important Safety Warnings Seek immediate medical attention if you experience: Severe, persistent abdominal pain (possible pancreatitis) Signs of dehydration from vomiting or diarrhea (dizziness, decreased urination, extreme thirst) Symptoms of gallbladder disease (right upper quadrant pain, fever, yellowing of skin or eyes) Severe hypoglycemia (confusion, loss of consciousness, seizures) Allergic reactions (difficulty breathing, swelling of face or throat, severe rash) Vision changes (if diabetic) Rapid or irregular heartbeat with chest discomfort Do not use semaglutide if you have: Personal or family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Known hypersensitivity to semaglutide or any formulation components Pregnancy or plans to become pregnant (discontinue at least 2 months before conception) Use with caution if you have: History of pancreatitis, severe gastrointestinal disease, diabetic retinopathy, kidney disease, or are taking insulin or sulfonylureas
This lack of selectivity raised concerns about chronic HPA axis activation with potential adverse metabolic consequences
A standard evaluation includes IGF-1, a complete metabolic panel, thyroid function, fasting glucose, and a hormonal panel appropriate for the patients cycle status
B., Grnbaek, H., rskov, H., Tygstrup, N., & Vilstrup, H
