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AOD9604 is not FDAapproved for any medical indication, and FDA advisory documents note concerns about immunogenicity, peptide-related impurities, and lack of sufficient safety and efficacy data

As cheaper versions become widely available, adherence and continuity of care could become major concerns

97 Early findings also suggest potential protection against Alzheimers-related cognitive decline and co-morbidities 98

Notably, with a significant 29% risk reduction when looking at three or more years exposure to GLP-1RA. They added, Our sensitivity analysis supported the finding of risk reduction when looking at users of GLP-1RA. These findings support the possibility of GLP-1RA being an adjunctive therapy to IOP-reducing eye drops in glaucoma management, the authors argue