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E2 appears to mediate many of these changes through rapid effects on HDL-C elevation (e.g., via reduced hepatic lipase activity) and longer-term reductions in TC and LDL-C (e.g., via upregulated LDL receptors), whereas P4 may exert counter-regulatory or anti-estrogenic actions [132]

This leads to enhanced wound healing, stimulation of dermal fibroblasts, and anti-aging effects through extracellular matrix remodeling

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414 Cell-penetrating peptides (CPPs) CPPs are a short peptide class consisting of 530 amino acids that can cross the cell membrane directly