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FIGURE 2 3.3 Daphnetin alleviated inflammation of diabetes cognitive dysfunction rats Figure 3 showed that daphnetin could alleviate STZ-caused inflammation in rat brain, which reduced the contents of IL-1, TNF, IL-6 and NF-B, and the mRNA expressions of IL-1, TNF, IL-6, iNOS and COX2

10, the DFU-GP group showed significantly elevated IL-6, IL-17, and TNF- compared with the normal control (NC-GP), confirming that chronic inflammation is central to DFU pathogenesis

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