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These comparative results align with the arm-level results for respective trials, with liraglutide having the smallest change from baseline (range 6.6% to 9.2%), followed by tirzepatide 5 mg ( 16.0%), semaglutide (range 16.6% to 17.1%), tirzepatide 10 mg ( 21.4%) and tirzepatide 15 mg ( 22.5%) (Supplementary Material Table S9)

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Regulatory Issues: Some pharmacies are using unapproved salt forms of semaglutide, which do not comply with FDA standards for compounded drugs