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It was effectively applied either immediately (prophylactically) after paracetamol challenge or (therapeutically) administered after a 3 h period had elapsed (note, the maximum depletion of hepatic glutathione occurred 3 h after acute paracetamol dosing (37))

Metabolic rate typically remains stable or increases on GLP-1 therapy, even with intermittent fasting, as long as you avoid chronic undereating

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