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In individuals with PLPBP mutations, the most common metabolic abnormality is an increase in blood lactate and glucose levels, leading to metabolic acidosis shortly after birth, typically on day 1, then returns to normal by day 3 to 4 [11]

Thats why I say its intriguing. Despite such logical reservations, I asked more than a dozen people I interviewed about side effects and heard only a few anecdotes about minor issues (in one case, stomach problems caused by an athlete screwing up dosages with a mislabeled vial)