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Oral semaglutide was superior to placebo and other antihyperglycemic drugs, such as iDPP4 (sitagliptin), iSGLT2 (empagliflozin) or other arGLP-1 (liraglutide) in reducing HbA1c or weight.116 Oral semaglutide was well tolerated, with a safety profile similar to that of other arGLP-1 s

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Protocols and their amendments are publicly accessible in ClinicalTrials.gov under the National Clinical Trial (NCT) identifiers NCT06659744, NCT07088718 and NCT07096063, and in the Open Science Framework (osf.io/38rw9) 43