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When They Should Not Be First-Line Therapy Despite their efficacy, novel weight loss peptides should generally not replace GLP-1 or GIP receptor agonists as initial therapy for uncomplicated obesity

This approval comes after thorough clinical trials that check for safety and effectiveness

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fragment-specific activity review: PMC8724243 TB-4 / TB-500 product mislabeling documented bidirectional mislabeling between full-length TB-4 (43 aa) and the TB-500 fragment (residues 1723) in marketed peptide products: Esposito M et al