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Figure 1 Production of toxic substances Many microorganisms have been shown to produce compounds that can cause DNA damage, cell cycle arrests, and genetic material instability, such as Escherichia coli and other Enterobacteriaceae bacteria code for polydactyl synthase, which produces Colibactin

Transcriptomic profiling revealed the role of apigenin-4-O--L-rhamnoside in inhibiting the activation of rheumatoid arthritis fibroblast-like synoviocytes via MAPK signaling pathway

Thus, antioxidants could expose these cells to reductive stress, which is also associated with cellular dysfunctionality 114,115