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Since men produce more creatinine due to greater muscle mass, their baseline creatinine clearance values are higher than those observed in women (Cockcroft and Gault 1976)

Vitamin B12 supplements are generally considered safe when taken in appropriate dosages

32,43 Moreover, because of the heterogeneous nature of tumors, there are considerable variations in NADPH-related processes in different tumors, for example, the main pathways of glutamine metabolism in the context of PDAC are different from the previous prevailing view as informed by studies of other cancers, 159,192 indicating the need for careful analyses of individual characteristics among cancers for establishing individualized precision therapy