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These treatments are not recommended for people with personal or family history of medullary thyroid cancer, multiple endocrine neoplasia syndrome type 2, severe gastroparesis, or during pregnancy

Risk factors for hemorrhage include the use of NSAIDs, lack of dietary fiber, constipation, and advancing age.10-12 Bleeding usually ceases spontaneously, with less than 1% of patients requiring greater than 4 units of blood.9 However, bleeding can become more hemodynamically significant in elderly patients with comorbid conditions, such as cerebrovascular disease or atherosclerotic cardiovascular disease, and in those with polypharmacy who may be taking anticoagulants or NSAIDs