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The glucagon component increases energy expenditure, making it ideal for patients experiencing metabolic slowdown or those at risk of regaining weight

As a result, patients with largely postprandial hyperglycaemia are more likely to benefit from treatment with short-acting GLP1-RAs as opposed to individuals with predominantly fasting hyperglycaemia, who would derive greater benefit from long-acting agents [52]

Tirzepatide goes further by activating both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors, creating a dual-hormone effect that some patients find more effective for weight reduction and metabolic improvement

doi: 10.3390/molecules17055404 123