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Material and methods Animals The Eighteen Olkuska sheep were selected for the study, 9 of which were ewes at the age of 2 years (multiparas) and 9 were 14 months of age (primiparas) whose selection was based on type of birth (maximum 5 day difference between partiturations and only twin births) and health status

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Early amylin analog development was marked by pramlintide's modest clinical impact (~23% weight loss) and poor adherence due to three-times-daily dosing