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The effect of SOD is dose-dependent

Nat Immunol (2007) 8(1):318

For example, the mitophagy inducer Urolithin A prevented ARHL in mice by enhancing the clearance of damaged mitochondria and improving mitochondrial DNA integrity and ATP production in the auditory system (Cho et al., 2024)

Although this study showed no cytotoxic effects of the analogues on cells at the highest concentration (3.25 mmol/L), or any visible adverse effects on rats at near the maximum equivalent human dose for GSH (1000 mg/kg), it is worth noting that the long-term effects and analysis of the effects of the analogues metabolites were beyond the scope of this study