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A systematic review and GRADE-assessed dose-response meta-analysis reported clinically relevant reductions in body weight and waist circumference among subjects with prediabetes and type 2 diabetes receiving turmeric or curcumin ( Bioavailability as the central translational barrier Bioavailability constitutes the principal pharmacological limitation of curcumin therapy, and this claim warrants substantive elaboration given its centrality to the precision adjunct argument

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