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Lewin and Lavon employed coenzyme Q10 both in vivo and in vitro and revealed that the incorporation of 50 mmol in vitro caused a significant improvement in motility, whilst in vivo incorporation of 60 mg/day for almost four months resulted in an enhancement in the fertilization rate but did not provide any impact on motility, morphology or concentration in 17 patients with decreased fertilization rates after in vitro fertilization with intracytoplasmic sperm injection for male factor infertility [96]