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Article Text According to current management guidelines, the success or failure of antiviral therapy for chronic hepatitis C is best assessed by hepatitis C virus (HCV) RNA testing using assays sensitive to a level of at least 100 IU/mL.[1][2] Patients who test HCV RNA-negative by such assays at least 24 weeks after completion of therapy are considered to have a sustained virological response (SVR), a critical endpoint associated with durable eradication of infection and long-term remission, if not cure, of disease.[3-6] HCV RNA testing during therapy is also helpful for indicating whether a virological response has occurred and for predicting the likelihood of an eventual SVR with prolongation of therapy