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However, the high expression of PLC-2 in low-invasive tumor cells can also prevent the malignant progression related to hypoxia (59), that is, PLC-2 can increase the level of E-cadherin in cells, block the up-regulation of CD133, and induce the adhesion of tumor cells to reduce their metastasis and invasion activity, thus preventing the progression of breast malignant tumors ( Figure 3 ) (57)

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