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In a rat model of adjuvant-induced arthritis, the combination of metformin (200 mg/kg/day) and omega-3 (300 mg/kg/day) showed efficacy comparable to methotrexate (2 mg/kg/week) in ameliorating disease activity, with significant reductions in arthritic scores, paw swelling, and serum TNF- and IL-1 after 4 weeks (252)

Mitapivat markedly reduced erythrophagocytosis in spleens of 4.2 / mice when compared with 4.2 / controls (Figure 4B)

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Thus, the main threat associated with severe HTG with fasting chylomicronaemia is acute pancreatitis (AP) [99, 213]