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It's well known that individuals with SZ are prone to metabolic irregularities and bioenergetic dysfunction [1, 36]

CKD stages 25 were identified using ICD-10-CM codes (N18.2, N18.3, N18.4, N18.5) or evidence of 2 estimated glomerular filtration rates (eGFRs) 89 mL/min/1.73m 2

Recently, LEADER (Liraglutide Effect and Action in Diabetes: Evaluation of cardiovascular outcome Results) study shows that GLP-1 analogue liraglutide treatment reduces the rates of cardiovascular events and death in patients with type 2 diabetes 9

In practice, most clinicians would likely taper tirzepatide down before initiating retatrutide to manage overlapping GI side effects and assess the new compound's individual response