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They are not associated with cardiovascular protection beyond glucose lowering, so they are typically chosen when GLP-1 agonists or SGLT2 inhibitors are unsuitable
Estrogen Exposure and Adipose-Driven Hormonal Modulation Because adipose tissue produces estrogen via aromatase, reductions in visceral fat can lower peripheral estrogen levels in some individuals
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Second, this contamination can directly interfere with your assay or experiment
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