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Today, AOD-9604 remains a topic of scientific interest, not as an approved therapy, but as a case study in how translational challenges can derail promising preclinical results

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This pharmacological profile makes it uniquely well-suited as the GHS-R1a component of a dual-receptor combination, adding acute calcium-dependent GH vesicle release without the adrenal or gonadal axis interference that complicates use of other GHRPs

The impact of INSL-5 on glucose control in mice also appears dependent on the mode of glucose delivery, as blood glucose or insulin levels were similar in Insl5 / mice compared to WT following an oral glucose test (164, 168)