Goldberg I, Eckel R, McPherson R
rotata aqueous extract (30, 100, 300, 1,000, and 3,000 mg/kg) produced dose-dependent reductions in mechanical allodynia in ipsilateral paws without significantly affecting contralateral paw thresholds [71]
Tirzepatides glucagon-receptor occupancy stays under 0.3% even at 15 mg. So its liver-fat reduction, its lipid improvements, and its heart-rate rise do not run through a glucagon arm the way retatrutides do
With new clinical trials of APR-246 commencing in multiple tumour streams 2 , our discovery of SLC7A11 expression as a robust companion biomarker, in addition to mut-p53 status, for APR-246, may facilitate selection and enrichment of patients with mut-p53 tumours who are most likely to respond to APR-246 therapy